Erasmus Urology Research

Extracellular Vesicles and Nanobodies

Circulating and excreted extracellular vesicles derived from prostatic cells are of growing interest, as their contents include genomic and proteomic information representative for the intracellular metabolism. Quantification and contents are studied by patented techniques.

Extracellular vesicles (exosomes) as biomarker treasure chests and their function and therapeutic applications in prostate cancer

All cells secrete small extracellular vesicles (EVs) that contain RNA, metabolites and protein from their host. From the number and content of plasma and urine EVs, the presence of disease can be determined. Besides their biomarker potential, the role of EVs in cancer progression and their use as therapeutic agents is being explored. (Guido Jenster)

 

Extracellular vesicles (EVs) function in PCa

EVs are emerging as important factors in the formation of a pre-metastatic niche. Improved understanding of their exact role and the development of strategies that inhibit EV mediated communication will provide opportunities for novel therapeutic strategies to inhibit prostate cancer growth and metastasis. (Martin van Royen)

 

Extracellular vesicles (EVs) as cancer biomarkers

Tumor EVs are important sources for biomarkers to characterize (malignant) cells from which they originate and can be found in body fluids including urine. With this in mind we developed EVQuant, a high-throughput microscopy assay for analysis of individual EVs. We will develop it further as minimally-invasive method for diagnosis and prognosis of prostate cancer. (Martin van Royen)

Novel nanobodies against cancer

Antibodies are an essential tool for diagnosis, imaging and treatment of cancer. Surprisingly, very few cancer-specific antibodies are available and we have developed a unique pipeline to select small antibodies (nanobodies) that recognize a specific (cancer) cell type. Generating unique nanobodies against urological cancers will provide novel tools to diagnose and treat disease. (Guido Jenster)

 

People working on the project

Guido Jenster

Guido Jenster

Full Professor

Martin van Royen

Martin van Royen

Principle Investigator

Ardalan Mansouri

Ardalan Mansouri

PhD-candidate

Natasja Dits

Natasja Dits

Research Technician

Joke Veldhoven

Joke Veldhoven

Research Technician

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