Erasmus Urology Research
The Erasmus DSD (differences of sex development) Expertise Center has been involved in clinical, translational and basic research since 1977, covering all aspects of DSD. The scientific output had a significant impact on patient-important issues. DSD is an umbrella term for many different and mostly rare congenital conditions that affect the development of the reproductive organs. Treatment of patients with DSD is complex and requires a multidisciplinary approach. There is a scarcity of data on long-term outcomes and our center has strived to generate information to enable better counseling and treatment of patients with a DSD condition. Our efforts resulted in numerous publications reporting on outcomes such as gonadal germ cell cancer risk, genetic factors, psychosocial and gender identity development, sexual function and quality of life.
Gonadal, in particular testicular development based on normal embryonic development as the starting point, which will hopTefully lead to a better classification of the aberrant gonadal development in patients with conditions such as DSD and cryptorchidism.
Gonadal cell cancer risk
Better knowledge of the germ cell cancer risk in specific conditions has led to revision of recommendations. Read more
Functional (neuro) urology
Children can present with various forms of bladder dysfunctions with neurogenic or non-neurogenic pathology. Research focusses on improving clinical symptoms and also quality of life. Read more
Fertility preservation in DSD
Individuals with DSD have often an impaired fertility for a variety of reasons, including aberrant gonadal and genital development, abnormal position of the testis and early gonadal failure with sex steroid deficiency. Read more
The Dutch Hypospadias Study determines the results of different surgical techniques and different surgeons, analyzes prognostic non-modifiable factors and modifiable surgical and non-surgical factors and identifies techniques with the lowest complication rates and best appearance and functional outcomes (“best practices”). Read more
Fred van der Toorn
pediatric urologist FEAPU
Lisette 't Hoen